Safety assessment of Piper cemuum Veil. (Piperaceae) leaves extract: Acute, sub-acute toxicity and genotoxicity studies

摘要

Ethnopharmacological relevance: Piper cemuum Veil (Piperaceae) is a native species from Atlantic rain forest, popularly known as pariparoba. Its leaves have been commonly used by rural and urban communities from State of Sao Paulo, Brazil, to treat pain (orally and topically), and hepatic and renal complications.