Tris(hydroxymethyl)methyl ammonium salts of biologically active carboxylic acids. Synthesis, properties and crystal structure

摘要

Tris(hydroxymethyl)methyl ammonium salts, [C(CH2OH)(3)NH3]X, were obtained for the first time by the interaction of tris(hydroxymethyl)aminomethane (TRIS) with carboxylic acids (cinnamic, benzoic, salicylic, nicotinic, 2-methylphenoxyacetic, succinic, malonic, oxalic, malic and citric). The new compounds (1-15) were characterized by H-1 NMR, C-13 NMR, FT-IR, elemental analysis and thermal analysis methods. The crystal structures of the tris(hydroxymethyl)methyl ammonium hydrogen malonate, hydrogen succinate and 2-methylphenoxyacetate were determined by the single-crystal X-ray diffraction. The antimicrobial activity of some synthesized tris(hydroxymethyl)methyl ammonium salts against bacteria Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis and fungi Candida albicans and Aspergillus niger has been investigated. (C) 2020 Elsevier B.V. All rights reserved.