Optimization of ciprofloxacin release kinetics of novel Nano-bioactive glasses: Effect of glass modifier content on drug loading and release mechanism

摘要

This work aimed to prepare novel nano-bioactive glass compositions, belonging to the SiO2-CaO system, for local ciprofloxacin administration. As a new approach, drug loading and its release kinetics of glass nanoparticles were optimized by increasing the modifier content at the expense of glass former. Four different Glass samples, of 3.2, 13.8, 24.2, and 34.5 mol% CaO content, were prepared (coded as CS1, CS2, CS3 and CS4, respectively). They were characterized by TEM, DSC, TGA and FTIR. The glass samples exhibited specific surface areas of 299.3, 140.5, 81.59, and 17.58 (m(2).g(-1)), respectively. A strong correlation was established between the modifier contents of the glass samples and drug loading or release doses. Modeling the drug release profiles of all glass samples confirmed that drug was released via a controlled diffusion mean. All glass samples induced hydroxyapatite layer onto their surfaces after immersion in simulated body fluid.