Synthesis, spectroscopic, thermal, biological, morphological and molecular docking studies of the different quinolone drugs and their cobalt(II) complexes

摘要

AbstractNew six cobalt(II) complexes1–6with four generation of quinolone drugs (nalidixic acid (Nal), oxolonic acid (Oxo), pipemidic acid (Pip), lomefloxacin (Lom), pefloxacin mesylate (Pef) and levofloxacin (Lev)) have been synthesized in methanol medium, and the general formula was designed as [Co(L)2(Cl)2(H2O)2]·4H2O (L=Nal (1), Oxo (2), Pip (3), Lom (4), Pef (5), and Lev (6)). The Co(III) complexes were identified using micro–analytical, FT–IR spectroscopy, conductance data, effective magnetic moments, electronic UV–vis spectra, and thermal analyses. The six quinolone drug chelates acts as uni–dentate via nitrogen atom of pyridone/piperazyl moiety. Electronic spectroscopic tools are in agreement with an octahedral geometrical structure. Thermal degradation analyses TG–DTG in nitrogen gas environmental are discussed the number and location of water molecules. The thermal decomposition process is completely in 3–4 steps, that the first step is responsible to loss of four uncoordinated water molecules. The stabilities of Co(II) complex1–6were studied dependent on activations of energy E*, entropy ΔS*, enthalpy ΔH* and Gibbs free energy ΔG* that have been estimated using Coats–Redfern and Horowitz–Metzeger non–isothermal methods. Molecular docking was used to predict the binding between some quinolone drugs with the receptor of breast can