A simultaneous screening and quantitative method for the multiresidue analysis of pesticides in spices using ultra-high performance liquid chromatography-high resolution (Orbitrap) mass spectrometry

摘要

Highlights?A unique screening and quantitation method for 199 pesticides in spices by UHPLC-Q-Orbitrap MS.?SPE clean-up with HLB effectively minimized matrix interferences and false signals.?The vDIA acquisition enabled high selectivity at the SDL (2–5?ng/g) and LOQ (10–20?ng/g).?Screening and quantitation at or below the EU-MRLs.?Quantitative performance of the validated HRMS method conformed to LC–MS/MS.AbstractA novel screening and quantitation method is reported for non-target multiresidue analysis of pesticides using ultra-HPLC-quadrupole-Orbitrap mass spectrometry in spice matrices, including black pepper, cardamom, chili, coriander, cumin, and turmeric. The method involved sequential full-scan (resolution?=?70,000), and variable data independent acquisition (vDIA) with nine consecutive