Acute oxaliplatin-induced thrombotic thrombocytopenic purpura: a case report and results from a cytoflourimetric assay of platelet fibrinogen receptor.

摘要

To the Editor: In their recent article, Niu and Mims described a patient with oxaliplatin-induced thrombotic thrombocytopenic purpura (TTP). Clinical evidence was supported by the ADAMTS13 (a disintegrin-like metalloprotease with thrombospondin type I motifs) metalloproteinase assay, and the authors postulated the role of an immune process as the principal underlying mechanism. We recently had a similar experience with a 68-year-old woman with liver and peritoneal metastases from colon cancer. The experimental aspect of our experience focused mainly on the sudden drop in platelet count and on the possibility of performing an affordable and dynamic platelet function test that could provide further valuable pathogenetic insights into the problem.