Elastic antibacterial membranes comprising particulate laden fibers for wound healing applications

摘要

Medicated skin care products are available in various forms; ranging from lotions and creams to bandages and membranes. In this study, antibacterial particulate laden fibrous membranes (FMs) were prepared via electrospraying of tetracycline hydrochloride-loaded poly(epsilon-caprolactone) particles alongside electrospinning of thermoplastic polyurethane (TPU) fibers, through which both mechanical and biological aspects of a complete membrane system can be achieved. Random (R) and ordered (P and V) patterns of TPU FMs were afforded using a rotating collector. Water contact angle and bacterial inhibition zone tests were performed to assess suitability of the system specifically for wound care. Stress-strain and in vitro drug release tests were performed to assess suitability of newly developed systems specifically for hybrid membranes (HMs). The highest tensile strength (32.1 +/- 4.9 MPa) with elasticity (104.2 +/- 6.0%) and the most sustained release rate indicate HMs (P) are potentially suitable materials for wound-care applications. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47105.