Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy A Randomized Clinical Trial

Shankaran Seetha; Laptook Abbot R.; Pappas Athina; McDonald Scott. A.; Das Abhik; Tyson Jon E.; Poindexter Brenda B.; Schibler Kurt; Bell Edward F.; Heyne Roy J.; Pedroza Claudia; Bara Rebecca; Van Meurs Krisa P.; Huitema Carolyn M. Petrie; Grisby Cathy; Devaskar Uday; Ehrenkranz Richard A.; Harmon Heidi M.; Chalak Lina F.; DeMauro Sara B.; Garg Meena; Hartley-McAndrew Michelle E.; Khan Amir M.; Walsh Michele C.; Ambalavanan Namasivayam; Brumbaugh Jane E.; Watterberg Kristi L.; Shepherd Edward G.; Hamrick Shannon E. G.; Barks John; Cotten C. Michael; Kilbride Howard W.; Higgins Rosemary D.

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Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy A Randomized Clinical Trial

机译：缺氧缺血性脑病的新生儿18个月内死亡或残疾冷却的深度和持续时间对随机临床试验

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IMPORTANCE Hypothermia for 72 hours at 33.5C for neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high.

机译：对于新生儿缺氧缺血性脑病减少死亡或残疾，在33.5℃下为33.5℃的重要性体温过低72小时，降低了死亡或残疾，但率继续高。

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《JAMA: the Journal of the American Medical Association》 |2017年第1期|共11页
作者
Shankaran Seetha; Laptook Abbot R.; Pappas Athina; McDonald Scott. A.; Das Abhik; Tyson Jon E.; Poindexter Brenda B.; Schibler Kurt; Bell Edward F.; Heyne Roy J.; Pedroza Claudia; Bara Rebecca; Van Meurs Krisa P.; Huitema Carolyn M. Petrie; Grisby Cathy; Devaskar Uday; Ehrenkranz Richard A.; Harmon Heidi M.; Chalak Lina F.; DeMauro Sara B.; Garg Meena; Hartley-McAndrew Michelle E.; Khan Amir M.; Walsh Michele C.; Ambalavanan Namasivayam; Brumbaugh Jane E.; Watterberg Kristi L.; Shepherd Edward G.; Hamrick Shannon E. G.; Barks John; Cotten C. Michael; Kilbride Howard W.; Higgins Rosemary D.;
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作者单位

Wayne State Univ Dept Pediat Detroit MI 48202 USA;

Brown Univ Women &

Infants Hosp Dept Pediat Providence RI 02908 USA;

Wayne State Univ Dept Pediat Detroit MI 48202 USA;

RTI Int Social Stat &

Environm Sci Unit Res Triangle Pk NC USA;

RTI Int Social Stat &

Environm Sci Unit Rockville MD USA;

Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Dept Pediat Houston TX 77030 USA;

Indiana Univ Sch Med Dept Pediat Indianapolis IN 46202 USA;

Cincinnati Childrens Hosp Med Ctr Perinatal Inst Cincinnati OH 45229 USA;

Univ Iowa Dept Pediat Iowa City IA 52242 USA;

Univ Texas Southwestern Med Ctr Dallas Dept Pediat Dallas TX USA;

Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Dept Pediat Houston TX 77030 USA;

Wayne State Univ Dept Pediat Detroit MI 48202 USA;

Stanford Univ Sch Med Dept Pediat Div Neonatal &

Dev Med Palo Alto CA 94304 USA;

RTI Int Social Stat &

Environm Sci Unit Rockville MD USA;

Cincinnati Childrens Hosp Med Ctr Perinatal Inst Cincinnati OH 45229 USA;

Univ Calif Los Angeles Dept Pediat Los Angeles CA 90024 USA;

Yale Univ Sch Med Dept Pediat New Haven CT 06510 USA;

Indiana Univ Sch Med Dept Pediat Indianapolis IN 46202 USA;

Univ Texas Southwestern Med Ctr Dallas Dept Pediat Dallas TX USA;

Univ Penn Childrens Hosp Philadelphia Perelman Sch Med Dept Pediat Philadelphia PA 19104 USA;

Univ Calif Los Angeles Dept Pediat Los Angeles CA 90024 USA;

SUNY Buffalo Dept Pediat Buffalo NY USA;

Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Dept Pediat Houston TX 77030 USA;

Case Western Reserve Univ Rainbow Babies &

Childrens Hosp Dept Pediat Cleveland OH 44106 USA;

Univ Alabama Birmingham Div Neonatol Birmingham AL USA;

Univ Iowa Dept Pediat Iowa City IA 52242 USA;

Univ New Mexico Hlth Sci Ctr Albuquerque NM 87131 USA;

Ohio State Univ Dept Pediat Nationwide Childrens Hosp Columbus OH 43210 USA;

Emory Univ Sch Med Dept Pediat Childrens Hlthcare Atlanta Atlanta GA USA;

Univ Michigan Dept Pediat Ann Arbor MI 48109 USA;

Duke Univ Dept Pediat Durham NC 27706 USA;

Childrens Mercy Hosp Dept Pediat Kansas City MO 64108 USA;

Eunice Kennedy Shriver Natl Inst Child Hlth &

Hum NIH Bethesda MD USA;

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正文语种 eng
中图分类医药、卫生;
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1. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy A Randomized Clinical Trial [J] . Shankaran Seetha, Laptook Abbot R., Pappas Athina, JAMA: the Journal of the American Medical Association . 2017,第1期

机译：缺氧缺血性脑病的新生儿18个月内死亡或残疾冷却的深度和持续时间对随机临床试验
2. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy A Randomized Clinical Trial [J] . Shankaran Seetha, Laptook Abbot R., Pappas Athina, JAMA: the Journal of the American Medical Association . 2014,第24期

机译：深度和冷却时间对新生儿缺氧缺血性脑病新生儿重症监护病房死亡的影响随机临床试验
3. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial EDITORIAL COMMENT [J] . Obstetrical and gynecological survey . 2018,第3期

机译：治疗体温过低在缺氧缺血性脑病的新生儿死亡或残疾后发起的治疗性低温结果：随机临床试验编辑评论
4. THE MODERATING EFFECT OF THE SEVERITY OF BASELINE MUSCULOSKELETAL DISCOMFORT ON THE EFFECT OF AN ALTERNATIVE KEYBOARD: A 5-MONTH RANDOMIZED CLINICAL TRIAL [C] . Nancy A. Baker, Krissy Moehling Human Factors and Ergonomics Society annual meeting . 2012

机译：基线肌肉骨骼不适严重程度对替代键盘的模拟效果：5个月随机临床试验
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. Functional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy [O] . GIRIJA NATARAJAN, SEETHA SHANKARAN, ATHINA PAPPAS, -1

机译：18个月大时的功能状态可预测新生儿缺氧缺血性脑病后的儿童残疾
7. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial [O] . Shankaran Seetha, Laptook Abbot R., Pappas Athina, 2014

机译：降温深度和持续时间对新生儿缺氧缺血性脑病新生儿重症监护病房死亡的影响：一项随机临床试验

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy A Randomized Clinical Trial

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