Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial

Wittekamp Bastiaan H.; Plantinga Nienke L.; Cooper Ben S.; Lopez-Contreras Joaquin; Coll Pere; Mancebo Jordi; Wise Matt P.; Morgan Matt P. G.; Depuydt Pieter; Boelens Jerina; Dugernier Thierry; Verbelen Valerie; Jorens Philippe G.; Verbrugghe Walter; Malhotra-Kumar Surbhi; Damas Pierre; Meex Cecile; Leleu Kris; van den Abeele Anne-Marie; Gomes Pimenta de Matos Ana Filipa; Fernandez Mendez Sara; Vergara Gomez Andrea; Tomic Viktorija; Sifrer Franc; Villarreal Esther; Ruiz Ramos Jesus; Aragao Irene; Santos Claudia; Sperning Roberta H. M.; Coppadoro Patrizia; Nardi Giuseppe; Brun-Buisson Christian; Bonten Marc J. M.

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Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial

机译：抗生素抗性微生物的去污策略和血流感染在通风患者中进行随机临床试验

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IMPORTANCE The effects of chlorhexidine (CHX) mouthwash, selective oropharyngeal decontamination (SOD), and selective digestive tract decontamination (SDD) on patient outcomes in ICUs with moderate to high levels of antibiotic resistance are unknown.

机译：重要性氯己定（CHX）漱口水，选择性口咽净化（SOD）和选择性消化道净化（SDD）对ICU中患者结果的影响，具有中度至高水平的抗生素抗性尚不清楚。

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《JAMA: the Journal of the American Medical Association》 |2018年第20期|共12页
作者
Wittekamp Bastiaan H.; Plantinga Nienke L.; Cooper Ben S.; Lopez-Contreras Joaquin; Coll Pere; Mancebo Jordi; Wise Matt P.; Morgan Matt P. G.; Depuydt Pieter; Boelens Jerina; Dugernier Thierry; Verbelen Valerie; Jorens Philippe G.; Verbrugghe Walter; Malhotra-Kumar Surbhi; Damas Pierre; Meex Cecile; Leleu Kris; van den Abeele Anne-Marie; Gomes Pimenta de Matos Ana Filipa; Fernandez Mendez Sara; Vergara Gomez Andrea; Tomic Viktorija; Sifrer Franc; Villarreal Esther; Ruiz Ramos Jesus; Aragao Irene; Santos Claudia; Sperning Roberta H. M.; Coppadoro Patrizia; Nardi Giuseppe; Brun-Buisson Christian; Bonten Marc J. M.;
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Univ Med Ctr Utrecht Julius Ctr Hlth Sci &

Primary Care Huispostnummer Str 6-131 POB 85500 NL;

Univ Med Ctr Utrecht Med Microbiol &

Julius Ctr Hlth Sci &

Primary Car Utrecht Netherlands;

Univ Oxford Nuffield Dept Clin Med Ctr Trop Med &

Global Hlth Oxford England;

Univ Autonoma Barcelona Infect Diseases Internal Med Hosp St Pau Barcelona Spain;

Univ Autonoma Barcelona Hosp St Pau Dept Microbiol Barcelona Spain;

Univ Autonoma Barcelona Hosp St Pau Dept Intens Care Barcelona Spain;

Univ Hosp Wales Adult Crit Care Cardiff S Glam Wales;

Univ Hosp Wales Adult Crit Care Cardiff S Glam Wales;

Ghent Univ Hosp Intens Care Ghent Belgium;

Ghent Univ Hosp Dept Lab Med Ghent Belgium;

Clin St Pierre Dept Intens Care Med Ottignies Belgium;

Clin St Pierre Microbiol Dept Ottignies Belgium;

Univ Antwerp Antwerp Univ Hosp Intens Care Med Antwerp Belgium;

Univ Antwerp Antwerp Univ Hosp Intens Care Med Antwerp Belgium;

Univ Antwerp Lab Med Microbiol Vaccine &

Infect Dis Inst Antwerp Belgium;

CHU Liege Dept Intens Care Med Liege Belgium;

CHU Liege Clin Microbiol Liege Belgium;

AZ Sint Jan Bruges Anesthesiol &

Crit Care Brugge Belgium;

St Lucas Hosp Ghent Microbiol Lab Ghent Belgium;

Ctr Hosp Tras os Montes os Montes &

Alto Douro Serv Med Intens Vila Real Portugal;

Hosp Clin Barcelona Med Intens Care Unit Barcelona Spain;

Hosp Clin Barcelona Microbiol Dept Barcelona Spain;

Univ Clin Resp &

Allerg Dis Lab Resp Microbiol Golnik Slovenia;

Univ Clin Resp &

Allerg Dis Intens Care Unit Golnik Slovenia;

Hosp Univ La Fe Intens Care Unit Valencia Spain;

Hosp Univ La Fe Intens Care Unit Valencia Spain;

CHP Intens Care UCIP Hosp Santo Antonio Porto Portugal;

CHP Microbiol Lab Hosp Santo Antonio Porto Portugal;

Azienda Osped San Camillo Forlanini Dept Microbiol Rome Italy;

Azienda Osped San Camillo Forlanini Intens Care Unit Rome Italy;

Osped Infermi RIMINI AUSL Romagna Dept Anesthesia &

Intens Care Rimini Italy;

CHU Henri Mondor Med Intens Care &

Infect Control Unit Paris France;

Univ Med Ctr Utrecht Med Microbiol &

Julius Ctr Hlth Sci &

Primary Car Utrecht Netherlands;

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正文语种 eng
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专利

1. Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial [J] . Wittekamp Bastiaan H., Plantinga Nienke L., Cooper Ben S., JAMA: the Journal of the American Medical Association . 2018,第20期

机译：抗生素抗性微生物的去污策略和血流感染在通风患者中进行随机临床试验
2. MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN). Effect of piperacillin- tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial (vol 320, pg 984, 2018) [J] . Harris P. N. A., Tambyah P. A., Lye D. C. JAMA: the Journal of the American Medical Association . 2019,第23期

机译：Merino试验员和澳大利亚传染病临床研究网络（ASID-CRN）。 Piperacillin-Tazobactam vs Meropenem对大肠杆菌或Klebsiella肺炎患者30天死亡率的影响：随机临床试验（Vol 320，PG 984,2018）
3. Central venous catheter-related bloodstream infections in patients with hematological malignancies: Comparison of data from a clinical registry and a randomized controlled trial [J] . Schalk Enrico, Teschner Daniel, Hentrich Marcus, Infection control and hospital epidemiology . 2020,第2期

机译：血液恶性肿瘤患者的中央静脉导管相关的血流感染：临床登记处和随机对照试验的数据比较
4. Data Mining Analysis of Relationship Between BloodStream Infection and Clinical Background in Patients Undergoing Lactobacillus Therapy [C] . Kimiko Matsuoka, Shigeki Yokoyama, Kunitomo Watanabe, New Frontiers in Artificial Intelligence . 2007

机译：乳酸菌治疗患者血流感染与临床背景关系的数据挖掘分析
5. Trials and tribulations: Using patients' and physicians' preferences to enhance the efficiency and ethics of randomized clinical trials [D] . Halpern, Scott David 2002

机译：试验和磨难：利用患者和医生的偏好来提高随机临床试验的效率和伦理
6. 7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial [O] . Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, 2018

机译：重症患者血液感染的抗生素治疗7天和14天：一项随机临床试验
7. Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients [O] . Bastiaan H. Wittekamp, Nienke L. Plantinga, Ben S. Cooper, 2018

机译：通风患者抗生素微生物的去污策略和血流感染

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial

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