Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial

Bachert Claus; Mannent Leda; Naclerio Robert M.; Mullol Joaquim; Ferguson Berrylin J.; Gevaert Philippe; Hellings Peter; Jiao Lixia; Wang Lin; Evans Robert R.; Pirozzi Gianluca; Graham Neil M.; Swanson Brian; Hamilton Jennifer D.; Radin Allen; Gandhi Namita A.; Stahl Neil; Yancopoulos George D.; Sutherland E. Rand

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Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial

机译：皮下杜帕里米亚对慢性鼻炎患者鼻息肉负担的影响，随机临床试验

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IMPORTANCE Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.

机译：Importance Dupilumab已经证明患有哮喘和特应性皮炎的疗效，这是2型辅助T细胞介导的疾病。

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来源
《JAMA: the Journal of the American Medical Association》 |2016年第5期|共11页
作者
Bachert Claus; Mannent Leda; Naclerio Robert M.; Mullol Joaquim; Ferguson Berrylin J.; Gevaert Philippe; Hellings Peter; Jiao Lixia; Wang Lin; Evans Robert R.; Pirozzi Gianluca; Graham Neil M.; Swanson Brian; Hamilton Jennifer D.; Radin Allen; Gandhi Namita A.; Stahl Neil; Yancopoulos George D.; Sutherland E. Rand;
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作者单位

Ghent Univ Hosp Dept Otorhinolaryngol Upper Airway Res Lab De Pintelaan 185 B-9000 Ghent;

Sanofi Res &

Dev Chilly Mazarin France;

Univ Chicago Chicago IL 60637 USA;

Hosp Clin Barcelona Inst Invest Biomed August Pi &

Sunyer Barcelona Spain;

Univ Pittsburgh Med Ctr Pittsburgh PA USA;

Ghent Univ Hosp Dept Otorhinolaryngol Upper Airway Res Lab De Pintelaan 185 B-9000 Ghent;

Univ Hosp Leuven Expt Immunol Lab Dept Otorhinolaryngol Head &

Neck Surg Leuven Belgium;

Sanofi Res &

Dev Bridgewater NJ USA;

Sanofi Res &

Dev Bridgewater NJ USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Sanofi Res &

Dev Bridgewater NJ USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Sanofi Res &

Dev Bridgewater NJ USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Regeneron Pharmaceut Inc Tarrytown NY USA;

Sanofi Res &

Dev Immunol &

Inflammat Dev Franchise Cambridge MA USA;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
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入库时间 2022-08-19 19:21:31

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专利

1. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial [J] . Bachert Claus, Mannent Leda, Naclerio Robert M., JAMA: the Journal of the American Medical Association . 2016,第5期

机译：皮下杜帕里米亚对慢性鼻炎患者鼻息肉负担的影响，随机临床试验
2. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials [J] . Bachert Claus, Han Joseph K., Desrosiers Martin, The Lancet . 2019,第10209期

机译：Dupilumab在鼻息肉患者中杜帕里姆（Dupilumab）患者的疗效和安全性（Liberty NP Sinus-24和Liberty NP Sinus-52）：两种多期，随机，双盲，安慰剂控制，并联 - 组3试验结果
3. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials (vol 394, pg 1638, 2019 [J] . Bachert C., Han J. K., Desrosiers M. The Lancet . 2019,第10209期

机译：Dupilumab在鼻息肉患者严重慢性鼻窦炎患者的疗效和安全性（Liberty NP Sinus-24和Liberty NP sinus-52）：两种多期，随机，双盲，安慰剂控制，并联 - 组3试验结果结果（ Vol 394，PG 1638,2019
4. Signal Pathway in Sinusitis, Polyps and Normal Nasal Mucosa through Bioinformatics Analysis on Differentially Expressed-Proteins [C] . Chen, Xuedong, Tang, Faqing, Sun, Hong International Conference on Biomedical Engineering and Informatics;BMEI '09 . 2009

机译：通过差异表达蛋白的生物信息学分析鼻窦炎，息肉和正常鼻黏膜的信号通路
5. Studying histamine, IL-5, IgE and TGF-beta1 in the pathogenesis of nasal polyposis [D] . Jokuti, Adrienn 2008

机译：研究组胺，IL-5，IgE和TGF-β1在鼻息肉病发病中的作用
6. A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) [O] . Nader Akbari Dilmaghani, Nadereh Alani, Sepideh Fazeli 2019

机译：元素锌附加疗法对慢性鼻鼻窦炎合并鼻息肉病（CRSwNP）患者临床疗效的随机临床试验
7. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial [O] . Bachert, Claus, Mannent, Leda, Naclerio, Robert M, 2016

机译：皮下注射Dupilumab对慢性鼻窦炎和鼻息肉患者鼻息肉负担的影响：一项随机临床试验

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial

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