Toxicology and Applied Pharmacology-Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation

摘要

In parallel to the emergence of nanotechnology as an innovative enabling technology, many projects and studies on potential impacts of nanomaterials (NMs) on human health and the environment have advanced. NMs have been defined as "natural, incidental or manufactured materials] containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm-100 nm" (Anon, 2011). The