Evaluation of the impact of banking umbilical cord blood units with high cell dose for ethnically diverse patients

摘要

BACKGROUNDUmbilical cord blood units provide an important stem cell source for transplantation, particularly for patients of ethnic diversity who may not have suitably matched available, adult-unrelated donors. However, with the cost of cord blood unit acquisition from public banks significantly higher than that for adult-unrelated donors, attention is focused on decreasing cost yet still providing cord blood units to patients in need. Historical practices of banking units with low total nucleated cell counts, including units with approximately 90 x 10(7) total nucleated cells, indicates that most banked cord blood units have much lower total nucleated cell counts than are required for transplant.