Anticonvulsant medications, such as gabapentin and pregabalin, are not effective for treating lower back pain and carry a risk of adverse events, the results of a systematic review and meta-analysis show. The research, published in the Canadian Medical Association Journal (3 July 2018), identified nine trials comparing topiramate or gabapentinoids with placebo, involving a total of 859 people with non-specific back pain, sciatica or neurogenic claudication.
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