Martin Than and colleagues provide a potential protocol for the most common and risk-filled issue in emergency medicine: the safe and appropriate discharge of emergency department patients with chest pain. Two obstacles are of note. First, a one-size-fits-all approach, despite being common, ignores Bayesian considerations and in low-risk groups results in poor yield. Than and colleagues address this by identifying a group whose post-test probability of an adverse event is low enough to consider foregoing further testing. The second obstacle is a pervasive beliefthattheacceptable "miss rate
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