Jagat Ram and colleagues (Oct 15, p 1501)1 describe an infant with bilateral spherophakia, megalocornea, and anterior lens dislocation, and report the systemic examination as being normal. I hope a genetic assessment was part of the clinical workup, since two genetic syndromes-congenital Marfan's syndrome2 and Weill-Marchesani syndrome3-can present with identical ocular findings in infancy. The photograph in fact seems to suggest the possibility of a depressed nasal bridge, bilateral epicanthic folds, and doubtful hypertelorism. Even in the absence of any dysmorphic features, there is a possibility that this infant is affected with biallelic LTBP2 mutations, which have been reported to be causative in the ocular phenotype of megalocornea, microspherophakia, and lens dislocation.
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