Mechanisms of Visceral Organ Crosstalk: Importance of Alterations in Permeability in Rodent Models

摘要

Purpose: The pathophysiology of painful bladder syndrome is poorly understood. However, there is evidence of female predominance and comorbidity with irritable bowel syndrome. Our hypothesis is that cross-sensitization between bladder and colon is due to altered permeability in 1 organ, which affects the other organ.