A Urine Based Genomic Assay to Triage Patients with Hematuria for Cystoscopy

van Kessel Kim E. M.; de Jong Joep J.; Ziel-van der Made Angelique C. J.; Roshani Hossain; Haensel Stefan M.; Wolterbeek Josien H.; Boeve Egbert R.; Oomens Eric H. G. M.; van Casteren Niels J.; Krispin Manuel; Boormans Joost L.; Steyerberg Ewout W.; van Criekinge Wim; Zwarthoff Ellen C.

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A Urine Based Genomic Assay to Triage Patients with Hematuria for Cystoscopy

机译：尿潴留血尿患者的基于尿基的基因组测定

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Purpose: Current clinical guidelines recommend cystoscopy in patients who present with hematuria to rule out a bladder tumor. We evaluated whether our previously developed urine assay was able to triage patients with hematuria for cystoscopy in a large prospective cohort.

机译：目的：当前临床指南推荐患有血尿患者的患者膀胱镜检查，以排除膀胱肿瘤。我们评估了我们以前发育的尿检是否能够在大型前瞻性队列中进行血尿患者的血尿患者。

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来源
《The Journal of Urology》 |2020年第1期|共7页
作者
van Kessel Kim E. M.; de Jong Joep J.; Ziel-van der Made Angelique C. J.; Roshani Hossain; Haensel Stefan M.; Wolterbeek Josien H.; Boeve Egbert R.; Oomens Eric H. G. M.; van Casteren Niels J.; Krispin Manuel; Boormans Joost L.; Steyerberg Ewout W.; van Criekinge Wim; Zwarthoff Ellen C.;
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作者单位

Erasmus Univ Inst Canc Dept Pathol Rotterdam Netherlands;

Erasmus Univ Inst Canc Dept Pathol Rotterdam Netherlands;

Erasmus Univ Inst Canc Dept Pathol Rotterdam Netherlands;

Haga Hosp Dept Urol The Hague Netherlands;

Haven Hosp Dept Urol Rotterdam Netherlands;

Haven Hosp Dept Urol Rotterdam Netherlands;

Franciscus Hosp Dept Urol Rotterdam Netherlands;

IJsselland Hosp Dept Urol Capelle aan den IJssel Netherlands;

MDxHealth Inc Irvine CA USA;

Erasmus Univ Inst Canc Dept Urol Rotterdam Netherlands;

Erasmus Univ Med Ctr Dept Publ Hlth Rotterdam Netherlands;

MDxHealth Inc Irvine CA USA;

Erasmus Univ Inst Canc Dept Pathol Rotterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
biomarkers; methylation; mutation; urinary bladder neoplasms; urinalysis;

机译：生物标志物;甲基化;突变;尿膀胱肿瘤;尿液分析;

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专利

1. A Urine Based Genomic Assay to Triage Patients with Hematuria for Cystoscopy [J] . van Kessel Kim E. M., de Jong Joep J., Ziel-van der Made Angelique C. J., The Journal of Urology . 2020,第1期

机译：尿潴留血尿患者的基于尿基的基因组测定
2. Re: Validation of a DNA Methylation-Mutation Urine Assay to Select Patients with Hematuria for Cystoscopy [J] . Wang Zhao, Bi Si-si, Wang Long The Journal of Urology . 2017,第6期

机译：Re：验证DNA甲基化 - 突变尿检，以选择血管镜检查血尿患者
3. A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma [J] . Laimonis Kavalieris, Paul J O’Sullivan, James M Suttie, BMC Urology . 2015,第1期

机译：从尿液样本中结合表型（临床特征）和基因型（基因表达）生物标志物的隔离指数，以分类出尿路上皮癌可能性较低的血尿患者
4. Quantification assay of imatinib in patient plasma and characterization of its metabolism in human urine and liver microsomes using LC-ESI-MS/MS [C] . A Deroussent, A Paci, C Delbaldo, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用LC-ESI-MS / MS的患者血浆患者血浆中伊马替尼对其代谢的表征及其尿液中的表征
5. Cystoscopy and the development of invasive bladder cancer in patients presenting with superficial urinary bladder cancer. [D] . Amos, Charles E., Jr. 2003

机译：膀胱镜检查和浅表性膀胱癌患者的浸润性膀胱癌的发展。
6. A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma [O] . Laimonis Kavalieris, Paul J O’Sullivan, James M Suttie, 2015

机译：从尿液样本中结合表型（临床特征）和基因型（基因表达）生物标志物的隔离指数以分类出尿路上皮癌可能性低的血尿患者
7. MP43-07 A URINE ASSAY TO TRIAGE PATIENTS WITH HEMATURIA FOR CYSTOSCOPY [O] . Kim van Kessel, Joep Jacobus de Jong*, Angelique Ziel-van der Made, 2019

机译：MP43-07尿液测定到患有血尿患者进行膀胱镜检查的患者
8. Development of an Assay for the Detection of PrPres in Blood and Urine Based on PMCA Assay and ELISA Methods [R] . Rohwer, R. G., Gregori, L. 2008

机译：基于pmCa分析和ELIsa方法的血液和尿液预处理检测方法的建立

A Urine Based Genomic Assay to Triage Patients with Hematuria for Cystoscopy

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