Pd(0)-Mediated C-11-Carbonylation of Aryl(mesityl)iodonium Salts as a Route to [C-11]Arylcarboxylic Acids and Derivatives

摘要

Pd(0)-mediated C-11-carbonylation of aryl-(mesityl)iodonium salts followed by suitable quench provides a rapid room-temperature two-pot procedure for labeling arylcarboxylic acids and amide derivatives with the short-lived positron emitter carbon-11 (t(1/2) = 20.4 min) in generally good to high yields (up to 71%). High product ring selectivity (>= 13) was achieved when using mesityl as a spectator group in the diaryliodonium salt precursors. This process has potential for preparing new radiotracers for molecular imaging with positron emission tomography.