A Domino Azidation/C-H Amination Approach toward Trifluoromethyl Substituted Imidazoles

摘要

N-Alkyl enarnines can be transformed into 2,4,5-trisubsituted iniidazoles by reacting with (diacetoxyiodo)benzene and TMSN3 under the catalysis of a copper salt such as Cu(OAc)(2). Tetrabutyl ammonium iodide was also capable of promoting, the reaction. The transformation from N-alkyl enamines into 2,4,5-trisubsituted imidazoles took place in a domino azidation/intramolecular C(sp(3))-H amination pattern. The present reaction provides a new efficient method for the preparation of 4-(trifluoromethyl) imidazoles.