<![CDATA[Synthesis of Bioactive 3,4-Dihydro-2H-naphtho[2,3-b][1,4]oxazine-5,10-dione and 2,3,4,5-Tetrahydro-1H-naphtho[2,3-b]azepine-6,11-dione Derivatives via the Copper-Catalyzed Intramolecular Coupling Reaction]]>

Hengyao You; Srinivas Rao Vegi; Chandraiah Lagishetti; Shuo Chen; R. Santhosh Reddy; Xiaohong Yang; Jian Guo; Chenhui Wang; Yun He

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机译：<！[CDATA [生物活性3,4-二氢-2的合成] -Naphtho [2,3- B] [1,4]恶唑-5,10- Dione和2,3,4,5-四氢-1 H + i> H，通过铜催化[2,3- B]偶氮-6,11-二酮衍生物分子内偶联反应]]>

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A convenient synthesis of 3,4-dihydro-2H -naphtho[2,3-b ][1,4]oxazine-5,10-diones and 2,3,4,5-tetrahydro-1H -naphtho[2,3-b ]azepine-6,11-diones via the copper-catalyzed intramolecular C–O/C–C coupling reaction is described. This method showed a good tolerance for functional groups and was applied to the synthesis of natural product core structures. Some coupling products exhibited moderate activities against lung cancer A549 cells.

机译：方便的合成3,4-二氢-2 H-NOHAphtho [2,3- B] [1,4]恶氨酸-5,10-二酮和2,3,4,5-四氢 - 1，通过铜催化的分子内C-O / C-C偶联反应描述1℃-Naphtho [2,3- B]萃戊酮-6,11-二乙基。该方法表现出良好的官能团耐受性，并应用于天然产物核心结构的合成。一些偶联产品表现出对肺癌A549细胞的适度活动。

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《The Journal of Organic Chemistry》 |2018年第7期|共12页
作者
Hengyao You; Srinivas Rao Vegi; Chandraiah Lagishetti; Shuo Chen; R. Santhosh Reddy; Xiaohong Yang; Jian Guo; Chenhui Wang; Yun He;
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School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

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1. [J] . Hengyao You, Srinivas Rao Vegi, Chandraiah Lagishetti, The Journal of Organic Chemistry . 2018,第7期

机译：<！[CDATA [生物活性3,4-二氢-2的合成] -Naphtho [2,3- B] [1,4]恶唑-5,10- Dione和2,3,4,5-四氢-1 H + i> H，通过铜催化[2,3- B]偶氮-6,11-二酮衍生物分子内偶联反应]]>
2. Naphtho(2,3-b)(1,4)-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. [J] . Tandon VK, Maurya HK, Yadav DB, Bioorganic and Medicinal Chemistry Letters . 2006,第22期

机译：萘并（2,3-b）（1,4）-噻嗪-5,10-二酮和3-取代的1,4-二氧代-1,4-二氢萘-2-基-硫代链烷酸酯衍生物：合成和生物学评价为潜在的抗菌和抗真菌剂。
3. Naphtho(2,3-b)(1,4)-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. [J] . Tandon VK, Maurya HK, Yadav DB, Bioorganic and Medicinal Chemistry Letters . 2006,第22期

机译：萘并（2,3-b）（1,4）-噻嗪-5,10-二酮和3-取代的1,4-二氧代-1,4-二氢萘-2-基-硫代链烷酸酯衍生物：合成和生物学评价为潜在的抗菌和抗真菌剂。
4. Regiospecific Synthesis of Pyrido(3,4-b)- and Pyrido(4,3-b)carbazole-5,11-dione Derivatives. Evaluation of Their In Vitro Antifungal or Antiprotozoological Activities. [O] . Ambroise POUMAROUX, Zouhair BOUAZIZ, Houda FILLION, 1999

机译：吡啶（3,4-B） - 和吡啶（4,3-B）咔唑-5,11-二酮衍生物的细胞细胞合成。评估其体外抗真菌或防拓性活动。
5. Phase Transfer Pd(O) Catalyzed Polymerization Reactions. 1. Synthesis of 1,2-(4,4'-Dialkoxyaryl)Acetylene Monomers and 1,4-Bis(2-(4',4''-Dialkoxyphenyl)Ethynyl)Benzene Derivatives by Phase Transfer Pd(O)/Cu(I) Catalyzed Coupling Reactions. [R] . Pugh, C., Percec, V. 1990

机译：相转移pd（O）催化的聚合反应。 1.相转移pd（O）/ Cu合成1,2-（4,4'-二烷氧基芳基）乙炔单体和1,4-双（2-（4'，4'-二烷氧基苯基）乙炔基）苯衍生物（I）催化的偶联反应。

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