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机译:<![CDATA [生物活性3,4-二氢-2的合成] -Naphtho [2,3- B] [1,4]恶唑-5,10- Dione和2,3,4,5-四氢-1 H + i> H,通过铜催化[2,3- B]偶氮-6,11-二酮衍生物 分子内偶联反应]]>

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摘要

A convenient synthesis of 3,4-dihydro-2H -naphtho[2,3-b ][1,4]oxazine-5,10-diones and 2,3,4,5-tetrahydro-1H -naphtho[2,3-b ]azepine-6,11-diones via the copper-catalyzed intramolecular C–O/C–C coupling reaction is described. This method showed a good tolerance for functional groups and was applied to the synthesis of natural product core structures. Some coupling products exhibited moderate activities against lung cancer A549 cells.
机译:方便的合成3,4-二氢-2 H-NOHAphtho [2,3- B] [1,4]恶氨酸-5,10-二酮和2,3,4,5-四氢 - 1,通过铜催化的分子内C-O / C-C偶联反应描述1℃-Naphtho [2,3- B]萃戊酮-6,11-二乙基。 该方法表现出良好的官能团耐受性,并应用于天然产物核心结构的合成。 一些偶联产品表现出对肺癌A549细胞的适度活动。

著录项

  • 来源
    《The Journal of Organic Chemistry》 |2018年第7期|共12页
  • 作者单位

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

    School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research Chongqing University 55 Daxuecheng South Road Shapingba Chongqing City 401331 P.R. China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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