Rotavirus disease and its prevention

摘要

The tremendous burden of rotavirus diarrhea among children all over the world continues to drive the remarkable pace of vaccine development and the variety of approaches to creating rotavirus vaccines,Rotavirus infection remains the most common cause of severe, dehydrating gastroenteritis among children worldwide. Almost every child in the world, in both developed and developing countries, will be infected with rotavirus in the first 5 years of life. Globally, approximately 500,000 children die every year from rotavirus gastroenteritis, with the vast majority of these deaths occurring in the poorest countries. In developed nations, rotavirus infection rarely results in death but remains the most common cause of hospitalizations for acute gastroenteritis in children and leads to major medical and societal costs.