Assessment of Nonalcoholic Fatty Liver Disease Progression in Children Using Magnetic Resonance Imaging

摘要

ObjectiveTo assess liver disease progression using paired magnetic resonance imaging (MRI) measurements of liver fat fraction (FF) and stiffness. Study designRetrospective cohort study including patients with nonalcoholic fatty liver disease who had undergone repeat MRI studies. Descriptive statistics were used, as well as Pearson or Spearman correlation when appropriate. Mixed model analyses were used to determine relationships between liver FF/stiffness and predictor variables. ResultsSixty-five patients (80% non-Hispanic, mean age 14?±?3 years) were included. Time from first to last MRI was 27?±?14 months. Over time, body mass index z score remained stable, and there were no significant differences in mean serum aminotransferases, insulin, glucose, triglycerides, low-density lipoprotein, and high-density lipoprotein (HDL) levels. However, the proportion of patients with alanine aminotransferase (ALT)?