Concise asymmetric total synthesis of lycopodine and flabelliformine via cascade cyclization reaction

摘要

The shortest asymmetric total synthesis of lycopodine (3) and the first asymmetric total synthesis of flabelliformine (4) were accomplished by a strategy that features a cascade cyclization of linear substrate (5) to construct tetracyclic structure (6). (C) 2018 Elsevier Ltd. All rights reserved.