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Concise synthesis of Licochalcone A through water-accelerated 3,3-sigmatropic rearrangement reaction
Concise synthesis of Licochalcone A through water-accelerated 3,3-sigmatropic rearrangement reaction
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机译:通过水促进的[3,3]-σ重排反应简捷合成Licochalcone A
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摘要
PURPOSE: A simple synthesizing method of licochalcone A is provided to use a water-acceleration [3,3]-sigmatropic transition reaction only without [1,3]-sigmatropic and deprenylation reactions. CONSTITUTION: A simple synthesizing method of licochalcone A marked with chemical formula 6 using 4-hydroxy-2-methoxybenzaldehyde marked with chemical formula 1 comprises a step of producing protected chalcone marked with chemical formula 4, using the claisen-Schmidt condensation reaction marked with chemical formula 2 and 3. In the chemical formula 3 and 4, R is a compound selected from alkyl or silyl. The alkyl is selected from methyl, benzyl, tetrahydropyranyl, methoxymethyl, or ethoxymethyl. The silyl is t-buthyldimethylsilyl or trimethylsilyl.
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