Anti-HIV natural products.

摘要

Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies. Despite continuous advances made in antiretroviral therapy, AIDS has become the leading cause of death in Africa and fourth worldwide; the number of people with HIV is increasing at an alarming rate in India and Southeast Asia. Biodiversity of the plant kingdom has always provided a source of new drug candidates for almost all disease areas. The number of compounds exhibiting anti-HIV activity and isolated from natural sources is increasing steadily. Calanolide A, a coumarin isolated from Callophyllum lanigerum [Calophyllum lanigerum] and 2 other natural product-derived molecules, DSB and 3-hydroxymethyl-4-methyl DCK are phase II clinical candidates, with potential to come up as drugs for treatment of HIV infection. Here, the natural products possessing anti-HIV activity have been discussed, with main focus on recent outcomes from natural sources as anti-HIV agents..