Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

摘要

Complexes 1-9 were synthesized by reacting metal precursors [(arene)MCl2](2) (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF6 as the counter ion. Ruthenium complexes exhibited N boolean AND O bonding mode while rhodium and iridium complexes exhibited N boolean AND N bonding mode with the migration of the N-H proton to the adjacent C=O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53(+/+)) and HCT116 p53 null (p53(-/-))] were carried out for all the complexes as well as ligands where interestingly, ligand 12 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity. (C) 2019 Elsevier Ltd. All rights reserved.