Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H2O2-induced apoptosis of PC12 cells

摘要

Eight previously undescribed sacculatane diterpenoids, epiphyllins A - H, and one unknown bibenzyl-based isopentene along with seven known compounds were isolated from the Chinese liverwort Pellia epiphylla (L) Corda. Their structures were established unequivocally on the basis of spectroscopic data and CD measurement. The quinine reductase-inducing activity evaluation demonstrated that epiphyllins A - D, 1 beta-hydroxysacculatanolide and pellianolactone B displayed moderate antioxidant effect. Further investigation of pellianolactone B revealed its protective effects on H2O2-induced oxidative insults and apoptosis in PC12 cells.