Monte Carlo and experimental determination of correction factors for gamma knife perfexion small field dosimetry measurements

摘要

Detector-, field size-and machine-specific correction factors are required for precise dosimetry measurements in small and non-standard photon fields. In this work, Monte Carlo (MC) simulation techniques were used to calculate the k(Qmsr,Qo) (fmsr,fref) and k(Qclin,Qmsr)(fclin,fmsr) correction factors for a series of ionization chambers, a synthetic microDiamond and diode dosimeters, used for reference and/ or output factor (OF) measurements in the Gamma Knife Perfexion photon fields. Calculations were performed for the solid water (SW) and ABS plastic phantoms, as well as for a water phantom of the same geometry. MC calculations for the k(Qclin,Qmsr)(fclin,fmsr) correction factors in SW were compared against corresponding experimental results for a subset of ionization chambers and diode detectors. Reference experimental OF data were obtained through the weighted average of corresponding measurements using TLDs, EBT-2 films and alanine pellets. k(Qmsr,Qo) (fmsr,fref) values close to unity (within 1%) were calculated for most of ionization chambers in water. Greater corrections of up to 6.0% were observed for chambers with relatively large air-cavity dimensions and steel central electrode. A phantom correction of 1.006 and 1.024 (breaking down to 1.014 from the ABS sphere and 1.010 from the accompanying ABS phantom adapter) were calculated for the SW and ABS phantoms, respectively, adding up to k(Qmsr,Qo) (fmsr,fref) corrections in water. Both measurements and MC calculations for the diode and microDiamond detectors resulted in lower than unit k(Qclin,Qmsr)(fclin,fmsr) correction factors, due to their denser sensitive volume and encapsulation materials. In comparison, higher than unit k(Qclin,Qmsr)(fclin,fmsr) results for the ionization chambers suggested field size depended dose underestimations (being significant for the 4 mm field), with magnitude depending on the combination of contradicting phenomena associated with volume averaging and electron fluence perturbations. Finally, the presence of 0.5 mm air-gap between the diodes' frontal surface and their phantom-inserts may considerably influence OF measurements, reaching 4.6% for the Razor diode.