Synthesis of a New Class of Phosphinic Acids: Synthesis of Novel Four-Membered Cyclic Oxaphosphetanes by Intramolecular Mitsunobu Reaction of Bis(alpha-hydroxyalkyl)phosphinic Acids

摘要

A novel class of phosphinic acid derivatives, four-mem-bered cyclic oxaphosphetanes, was synthesized by the reaction of bis(hydroxymethyl)phosphinic acids with a mixture of triphe-nylphosphine and diisopropyl azodicarboxylate in toluene-dichlo-romethane at room temperature via an intramolecular Mitsunobu reaction.