Palladium-Catalyzed Regioselective Coupling of Secondary Propargyl Carbonates and Ethyl 2-(pyridin-2-yl)acetate Derivatives: Facile Access to C-3 Benzylated Indolizines

摘要

A palladium-catalyzed ligand controlled regioselective -coupling reaction of secondary propargyl carbonates and ethyl 2-(pyridin-2-yl)acetate derivatives has been described, leading to C-3 benzyl-ated indolizines for the first time in moderate to good yields. DBFphos as the ligand is crucial to this high regioselective annulation reaction, and a plausible reaction mechanism has been proposed.