A facile regio- and stereoselective synthesis of novel spiro[indolin-3,2-pyrrolidin]-2-one's via 1,3-dipolar cycloaddition of azomethine ylides

摘要

A facile regio and stereoselective synthesis of novel spiro[indolin-3,2-pyrrolidin]-2-one's have been accomplished through 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reaction of isatin and benzyl amine with quinoline bearing dipolarophiles in good yields. The synthesized compounds were well characterized through different spectroscopic techniques, such as single crystal XRD, FTIR, NMR, and mass spectral analysis.