No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes

Krouwels Anita; Popov-Celeketic Jelena; Plomp Saskia G. M.; Dhert Wouter J. A.; Oner F. Cumhur; Bank Ruud A.; Creemers Laura B.

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No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes

机译：尽管上调细胞外基因基因，但是，尽管升高细胞外基因，但Hypermolar培养基对人退化的核髓细胞组织再生的影响

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摘要

Study Design. An in vitro study using human degenerated nucleus pulposus cells.

机译：学习规划。使用人退化的核浆细胞的体外研究。

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来源
《Spine》 |2018年第5期|共9页
作者
Krouwels Anita; Popov-Celeketic Jelena; Plomp Saskia G. M.; Dhert Wouter J. A.; Oner F. Cumhur; Bank Ruud A.; Creemers Laura B.;
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作者单位

Univ Med Ctr Utrecht Dept Orthoped HP G05-228 POB 85500 NL-3508 GA Utrecht Netherlands;

Univ Med Ctr Groningen Dept Pathol &

Med Biol Groningen Netherlands;

Univ Med Ctr Utrecht Dept Orthoped HP G05-228 POB 85500 NL-3508 GA Utrecht Netherlands;

Univ Med Ctr Utrecht Dept Orthoped HP G05-228 POB 85500 NL-3508 GA Utrecht Netherlands;

Univ Med Ctr Utrecht Dept Orthoped HP G05-228 POB 85500 NL-3508 GA Utrecht Netherlands;

Univ Med Ctr Groningen Dept Pathol &

Med Biol Groningen Netherlands;

Univ Med Ctr Utrecht Dept Orthoped HP G05-228 POB 85500 NL-3508 GA Utrecht Netherlands;

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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
aggrecan; collagen II; DNA.; GAG; hyperosmotic; intervertebral disc; nucleus pulposus; osmolality; osmolyte; sodium chloride; sucrose; urea;

机译：橡皮琴;胶原蛋白II;DNA;GAG;Hypermotic;椎间盘;核浆;渗透压;渗透压;渗透;氯化钠;蔗糖;尿素;尿素;尿素;

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专利

1. No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes [J] . Krouwels Anita, Popov-Celeketic Jelena, Plomp Saskia G. M., Spine . 2018,第5期

机译：尽管上调细胞外基因基因，但是，尽管升高细胞外基因，但Hypermolar培养基对人退化的核髓细胞组织再生的影响
2. Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue [J] . van Dijk Bart G. M., Potier Esther, van Dijk Maarten, Journal of tissue engineering and regenerative medicine . 2017,第7期

机译：成骨蛋白1不会刺激培养的人退化的核浆膜组织中的再生效果
3. Differential expression of extracellular-Signal-Regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells [J] . LiangW., FangD., YeD., Biochemical and Biophysical Research Communications . 2014,第4期

机译：细胞外信号调节激酶5（ERK5）在正常和退化的人核脉搏组织和细胞中的差异表达
4. Lower Macromer Concentration Enhances Nucleus Pulposus-Like Differentiation and Functional Extracellular Matrix Assembly by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels [C] . Gupta MS, Nicoll SB ASME summer bioengineering conference;SBC2012 . 2012

机译：较低的大分子单体浓度提高了髓核样分化和功能性细胞外基质组装的光致交联羧甲基纤维素水凝胶封装的人类骨髓基质细胞。
5. Characterization of Sodium Alginate as an Injectable Nucleus Pulposus Analogue for Height Restoration, Biofunctionalization and Cellular Regeneration of Degenerated Intervertebral Discs [D] . Kalaf, Emily A. Growney. 2017

机译：海藻酸钠作为可注射髓核类似物的表征，用于高度退化，椎间盘的生物功能化和细胞再生
6. Micro Fragmented Adipose Tissue Promotes the Matrix SynthesisFunction of Nucleus Pulposus Cells and Regenerates Degenerated IntervertebralDisc in a Pig Model [O] . Xiaopeng Zhou, Feng Zhang, Dawei Wang, 2020

机译：微碎裂的脂肪组织促进基质合成细胞核牙髓细胞的功能和再生退化椎间猪模型中的光盘
7. Are specific gene expressions of extracellular matrix and nucleus pulposus affected by primer cell cultures prepared from intact or degenerative intervertebral disc tissues? [O] . Numan Karaarslan, Ibrahim Yilmaz, Hanefi Ozbek, 2018

机译：是否具有由完整或退行性椎间盘组织制备的引物细胞培养物影响的细胞外基质和核瓜素的特异性基因表达？

No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes

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