Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas

Li Xianqi; Strasser Bernhard; Jafari-Khouzani Kourosh; Thapa Bijaya; Small Julia; Cahill Daniel P.; Dietrich Jorg; Batchelor Tracy T.; Andronesi Ovidiu C.

首页> 外文期刊>Radiology >Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas

【24h】

Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas

机译：超分辨率全脑3D MR光谱成像，用于在异柠檬酸脱氢酶1突变的人胶质瘤中映射D-2-羟基戊酸酯和肿瘤代谢

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background: Isocitrate dehydrogenase (IDH) mutations are highly frequent in glioma, producing high levels of the oncometabolite D-2-hydroxyglutarate (D-2HG). Hence, D-2HG represents a valuable imaging marker for IDH-mutated human glioma.

机译：背景：异柠檬酸脱氢酶（IDH）突变在胶质瘤中高度频繁，产生高水平的oncometabolite D-2-羟基戊酸酯（D-2Hg）。因此，D-2Hg代表IDH突变的人胶质瘤的有价值的成像标记。

著录项

来源
《Radiology》 |2020年第3期|共9页
作者
Li Xianqi; Strasser Bernhard; Jafari-Khouzani Kourosh; Thapa Bijaya; Small Julia; Cahill Daniel P.; Dietrich Jorg; Batchelor Tracy T.; Andronesi Ovidiu C.;
展开▼
作者单位

Massachusetts Gen Hosp AA Martinos Ctr Biomed Imaging Dept Radiol 149 13th St Suite 2301;

Massachusetts Gen Hosp AA Martinos Ctr Biomed Imaging Dept Radiol 149 13th St Suite 2301;

ICAD Nashua NH USA;

Massachusetts Gen Hosp AA Martinos Ctr Biomed Imaging Dept Radiol 149 13th St Suite 2301;

Massachusetts Gen Hosp Dept Neurosurg Boston MA 02114 USA;

Massachusetts Gen Hosp Dept Neurosurg Boston MA 02114 USA;

Massachusetts Gen Hosp Dept Neurol Boston MA 02114 USA;

Brigham &

Womens Hosp Dept Neurol 75 Francis St Boston MA 02115 USA;

Massachusetts Gen Hosp AA Martinos Ctr Biomed Imaging Dept Radiol 149 13th St Suite 2301;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类放射医学;
关键词

相似文献

外文文献
中文文献
专利

1. Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas [J] . Li Xianqi, Strasser Bernhard, Jafari-Khouzani Kourosh, Radiology . 2020,第3期

机译：超分辨率全脑3D MR光谱成像，用于在异柠檬酸脱氢酶1突变的人胶质瘤中映射D-2-羟基戊酸酯和肿瘤代谢
2. D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma [J] . Stefan Pusch, Leonille Schweizer, Ann-Christin Beck, Acta Neuropathologica Communications . 2014,第1期

机译：产生新酶活性的D-2-羟基戊二酸与神经胶质瘤中异柠檬酸脱氢酶1突变类型的频率成反比
3. Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia [J] . Zachary Reitman, Christopher Duncan, Ethan Poteet, The Journal of biological chemistry . 2014,第34期

机译：癌症相关的异柠檬酸脱氢酶1（IDH1）R132H突变和D-2-羟基戊酸酯在缺氧下刺激谷氨酰胺代谢
4. Multiclass brain Glioma tumor classification using block-based 3D Wavelet features of MR images [C] . Ghazanfar Latif, M. Mohsin Butt, Adil H. Khan, International Conference on Electrical Electronic Engineering . 2017

机译：使用基于块的MR图像3D小波特征进行多类脑胶质瘤肿瘤分类
5. Evaluation of Human Brain Metabolism using Five-Dimensional Echo Planar J-resolved Spectroscopic Imaging and Covariance J-resolved Spectroscopy. [D] . Iqbal, Zohaib. 2017

机译：使用五维回波平面J分辨光谱成像和协方差J分辨谱评估人脑代谢。
6. Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis [O] . Amanda J. Pickard, Albert S. W. Sohn, Thomas F. Bartenstein, 2016

机译：携带突变异柠檬酸脱氢酶脑肿瘤的小鼠体内合成代谢的d-2-羟基戊二酸的脑内分布：对肿瘤发生的影响。
7. Intracerebral Distribution of the Oncometabolite D-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis [O] . Amanda Pickard, Albert Sohn, Thomas Bartenstein, 2016

机译：具有突变异柠檬酸脱氢酶脑肿瘤的小鼠中谷胱甘肽D-2-羟基戊二酸的脑内分布：对肿瘤发生的影响

Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas

摘要

著录项

相似文献

相关主题

期刊订阅