Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

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Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

机译：BNIP3通过Caspase-3 / GSDME介导多柔比蛋白诱导的心肌细胞γγ

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Aims: This study was aimed to investigate the role of GSDME-mediated pyroptosis in cardiac injury induced by Doxorubicin (DOX), and to evaluate the role of BH3-only protein Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (Bnip3) in regulation of DOX-induced pyroptosis.

机译：目的：本研究旨在探讨GSDME介导的γ毒素对由多柔比星（DOX）诱导的心损伤的作用，并评估BH3蛋白Bcl-2 /腺病毒E1b 19-KDA相互作用蛋白3的作用（BNIP3 ）在调节DOX诱导的糊状腺症。

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《Life sciences》 |2020年第2020期|共9页
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正文语种 eng
中图分类医药、卫生;
关键词
Pyroptosis; Bnip3; GSDME; Caspase-3; Doxorubicin;

机译：辐射瘤;BNIP3;GSDME;Caspase-3;多柔比星;

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专利

1. Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME [J] . Life sciences . 2020,第期

机译：BNIP3通过Caspase-3 / GSDME介导多柔比蛋白诱导的心肌细胞γγ
2. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells [J] . Junhui Yu, Shan Li, Jie Qi, Cell death & disease. . 2019,第3期

机译：Caspase-3通过Caspase-3切割GSDME确定结肠癌细胞中的Lobaplatin诱导的γ凋亡
3. Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation [J] . Zhang Cheng-cheng, Li Chen-guang, Wang Yao-feng, Apoptosis: An international journal on programmed cell death . 2019,第3a4期

机译：化学治疗紫杉醇和顺铂在A549肺癌细胞中差异地诱导γ-3 / GSDME活化
4. Chronic Doxorubicin-Induced Cardiomyopathy: The Pathogenic Role of Calpain-Mediated Dystrophin Disruption [C] . Campos E.C., Celes M.R.N., Ferezin P., World Congress on Heart Disease . 2012

机译：慢性多柔比星诱导的心肌病：CALPAIN介导的营养不良蛋白中断的致病作用
5. The Role of p38 MAPK Mediated Paracrine Signaling from Cardiomyocytes to Endothelial Cells in vitro and in vivo. [D] . Rose, Beth Ann. 2010

机译：在体外和体内，p38 MAPK介导从心肌细胞向内皮细胞旁分泌信号传导的作用。
6. Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells [O] . Liang Yan, Yi Liu, Xue-feng Ma, 2021

机译：Triclabendazole通过激活Caspase-3来诱导糊菌以在乳腺癌细胞中切割GSDME
7. Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells [O] . Haein An, Jin Sun Heo, Pyunggang Kim, 2021

机译：通过在三阴性乳腺癌细胞中诱导Caspase-3 / GSDME的激活，增强线粒体RO的产生，促进糊衰落

Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

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