Correlation between mouse age and human age in anti-tumor research: Significance and method establishment

摘要

Age is closely related with the occurrence and development of tumors, and with treatment outcomes. To improve the accuracy and rigor of preclinical studies, and to enhance consistency between the preclinical research and the clinical reality, the age of experimental animals used in preclinical studies is important. The mouse genome is 99% identical to the human genome, and mice have similar patterns with respect to organs and systemic physiology. Thus, mice have been the most widely used animals in anti-tumor research. However, most mice used in such studies are 6 to 8 weeks old, ignoring the fact that different tumors may often occur in various periods, with a particular tendency to occur in later stages of life. The great difference in age limits the success rate of clinical transformation. Therefore, it is very important to choose mice of suitable age for preclinical studies and to correlate ages of human and mice. Only a few related studies have been reported and there is a lack of consistency in the findings. This review points out that age is one of the important factors in anti-tumor research, and establishes a new method for calculating the age correlation between humans and mice. The equations obtained from the method can help researchers conveniently determine suitable aged mouse for their research, which will improve the rigor of their experimental results. Furthermore, this method can be used beyond anti-tumor research, in studies on other diseases that use mouse as an animal model.