Activation of Ca(v)1.2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries

摘要

Aims: Caffeine is a methylxanthine with multiple actions in vascular smooth muscle cells (VSMCs), including the increase in the intracellular Ca2+ (Ca-i(2+)) concentration by the activation of ryanodine receptors (RyRs). The present study aimed at investigating the participation of Ca2+-influx through different Ca2+-channels on the transient contraction (TC) induced by caffeine in mice mesenteric arteries.