BUTYRYLCHOLINESTERASE-KNOCKOUT REDUCES BRAIN DEPOSITION OF FIBRILLAR beta-AMYLOID IN AN ALZHEIMER MOUSE MODEL

摘要

In Alzheimer's disease (AD), numerous beta-amyloid (A beta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops A beta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar A beta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar A beta in AD and this effect may be influenced by sex. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of IBRO.