Dual-radiotracer translational SPECT neuroimaging. Comparison of three methods for the simultaneous brain imaging of D-2/3 and 5-HT2A receptors

摘要

Purpose: SPECT imaging with two radiotracers at the same time is feasible if two different radioisotopes are employed, given their distinct energy emission spectra. In the case of I-123 and I-125, dual SPECT imaging is not straightforward: 123I emits photons at a principal energy emission spectrum of 143.1-179.9 keV. However, it also emits at a secondary energy spectrum (15-45 keV) that overlaps with the one of I-125 and the resulting cross-talk of emissions impedes the accurate quantification of I-125. In this paper, we describe three different methods for the correction of this cross-talk and the simultaneous in vivo [I-123] IBZM and [I-125] R91150 imaging of D-2/3 and 5-HT2A receptors in the rat brain.