compound of formula (i), method of treatment and / or prevention, d2 receptor agonizing method in one individual, d3 receptor antagonizing method in one individual, 5-ht1d receptor agonizing method in one individual, 5-ht1a receptor agonization in one individual, selective 5-ht1d receptor agonizing method instead of 5-ht1b receptor in one individual, 5-ht2c re-receptor selective agonizing method instead of 5-ht2a or 5 receptor -ht2b in one individual, method of 5-ht2c receptor agonization in one individual, method of providing functional antagonist activity at 5-ht2b receptor or 5-ht7 receptor, and, method of providing functional antagonist activity at adrenergic receptors in one individual

摘要

Isoergoline compounds and pharmaceutical compositions thereof are provided herein. In other embodiments, methods of treating, preventing or ameliorating a variety of medical disorders, such as, for example, rinsing, are provided herein using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, receptor agonization methods are provided herein, such as, for example, 5-ht1a, 5-ht1b, and 5-ht1d receptors, without 5-ht2b receptor agonization by use. of the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, methods of antagonizing 5-ht2b alpha2a and / or alpha2b adrenergic receptors are provided herein with the use of the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, methods of antagonizing the d2 and d3 receptor using the compounds and pharmaceutical compositions disclosed herein are provided herein.