Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions

Leuppi-Taegtmeyer Anne; Duthaler Urs; Hammann Felix; Schmid Yasmin; Dickenmann Michael; Amico Patricia; Jehle Andreas W.; Kalbermatter Stefan; Lenherr Christoph; Schwabedissen Henriette E. Meyer Zu; Haschke Manuel; Liechti Matthias E.; Krahenbuhl Stephan

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Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions

机译：羟考酮/纳洛酮的药代动力学及其在血液透析期间末期肾病患者中的代谢产物

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Background The pharmacokinetics of oxycodone in patients with end-stage renal disease (ESRD) requiring haemodialysis are largely unknown. Therefore, we investigated the pharmacokinetics of oxycodone/naloxone prolonged release and their metabolites in patients with ESRD during and between haemodialysis sessions.

机译：背景技术需要血液透析患者催产酮的羟考酮（ESRD）的药代动力学主要是未知的。因此，我们调查了羟考酮/纳洛酮的药代动力学延长释放及其在血液透析期间和血液透析次数之间的患者中的代谢物。

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来源
《Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association》 |2019年第4期|共11页
作者
Leuppi-Taegtmeyer Anne; Duthaler Urs; Hammann Felix; Schmid Yasmin; Dickenmann Michael; Amico Patricia; Jehle Andreas W.; Kalbermatter Stefan; Lenherr Christoph; Schwabedissen Henriette E. Meyer Zu; Haschke Manuel; Liechti Matthias E.; Krahenbuhl Stephan;
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作者单位

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

Univ Hosp Basel Transplantat Immunol &

Nephrol Basel Switzerland;

Univ Hosp Basel Transplantat Immunol &

Nephrol Basel Switzerland;

Univ Hosp Basel Transplantat Immunol &

Nephrol Basel Switzerland;

Med Univ Clin Nephrol &

Dialysis Liestal Switzerland;

Med Univ Clin Nephrol &

Dialysis Liestal Switzerland;

Univ Basel Dept Pharmaceut Sci Basel Switzerland;

Univ Bern Bern Univ Hosp Dept Gen Internal Med Clin Pharmacol &

Toxicol Bern Switzerland;

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

Univ Basel Div Clin Pharmacol &

Toxicol Dept Biomed Univ Hosp Basel Basel Switzerland;

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原文格式 PDF
正文语种 eng
中图分类器官移植术;
关键词
haemodialysis; naloxone; oxycodone; pharmacokinetics; renal failure;

机译：血液透析;纳洛酮;羟考酮;药代动力学;肾功能衰竭;

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Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions

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