ERVcaller: identifying polymorphic endogenous retrovirus and other transposable element insertions using whole-genome sequencing data

摘要

Motivation: Approximately 8% of the human genome is derived from endogenous retroviruses (ERVs). In recent years, an increasing number of human diseases have been found to be associated with ERVs. However, it remains challenging to accurately detect the full spectrum of polymorphic (unfixed) ERVs using whole-genome sequencing (WGS) data.