TMCrys: predict propensity of success for transmembrane protein crystallization

摘要

Motivation: Transmembrane proteins (TMPs) are crucial in the life of the cells. As they have special properties, their structure is hard to determine-the PDB database consists of 2% TMPs, despite the fact that they are predicted to make up to 25% of the human proteome. Crystallization prediction methods were developed to aid the target selection for structure determination, however, there is a need for a TMP specific service.