Consecutive Five-Component Ugi-4CR-CAL B-Catalyzed Aminolysis Sequence and Concatenation with Transition Metal Catalysis in a One-Pot Fashion to Substituted Triamides

摘要

The concatenation of the Ugi four-component synthesis and the CAL B-catalyzed aminolysis of the intermediary formed Ugi methyl ester products furnishes a novel consecutive five-component reaction for the formation of triamides. This one-pot process is excellently compatible with metal catalyzed processes, such as copper-catalyzed alkyne-azide cycloaddition and Suzuki cross-coupling or both in a one-pot fashion. These novel consecutive six-component syntheses represent a practical tool for synthesizing substrate libraries of complex triamide structures in a diversity-oriented fashion.