Domino Reactions of Chromone-3-carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2,3-c]coumarins and their Optical and Biological Activity

摘要

A series of new heteroannulated pyrido[2,3-c]- coumarins have been prepared by the domino reactions of chromone-3-carboxylic acid derivatives with electron-rich binucleophilic aminoheterocycles. The products contain the core structures of coumarin, pyridine, and an annulated fivemembered heterocyclic system, namely pyrazole, pyrrole, or isoazole. The fluorescence of the products was investigated. The products inhibit ecto-5'-nucleotidase (e5'NT) enzymatic activity.