Stereoselective Synthesis of Trisubstituted Epoxides Marks the Route to Chiral Building Blocks with Quaternary Centers

摘要

A facile access to enantiomerically pure derivatives of α-hydroxy-?-amino acids bearing a quaternary center and trifluoromethylated tertiary alcohols, which represent highly important building blocks for therapeutically relevant small molecules, has been efficiently achieved by developing an asymmetric epoxidation of α-activated ketones by employing chiral sulfur ylides.