Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

Tamura Shohei; Koike Yui; Takeda Hiroaki; Koike Tomonari; Izumi Yoshihiro; Nagasaka Ryosuke; Tsunoda Tetsuto; Tori Motoo; Ogawa Kazuo; Bamba Takeshi; Shiomi Masashi

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Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

机译：D-47，一种新开发的化合物，在家庭高胆固醇血症动物模型中对新开发的化合物（Whhlmi兔）的脂质代谢的改善效果

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摘要

Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein.

机译：本文研究了D-47的肝脏在肝脏脂质代谢中诱导的改进，是一种新开发的化合物。

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来源
《European Journal of Pharmacology: An International Journal》 |2018年第2018期|共7页
作者
Tamura Shohei; Koike Yui; Takeda Hiroaki; Koike Tomonari; Izumi Yoshihiro; Nagasaka Ryosuke; Tsunoda Tetsuto; Tori Motoo; Ogawa Kazuo; Bamba Takeshi; Shiomi Masashi;
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作者单位

Kobe Univ Grad Sch Med Dept Physiol &

Cell Biol Chuo Ku Div Comparat Pathophysiol Kusunoki Cho;

Inst Expt Anim Chuo Ku Kusunoki Cho Kobe Hyogo 6500017 Japan;

Kyushu Univ Med Inst Bioregulat Div Metabol Higashi Ku 3-1-1 Maidashi Fukuoka 8128582 Japan;

Inst Expt Anim Chuo Ku Kusunoki Cho Kobe Hyogo 6500017 Japan;

Kyushu Univ Med Inst Bioregulat Div Metabol Higashi Ku 3-1-1 Maidashi Fukuoka 8128582 Japan;

Kobe Univ Grad Sch Med Dept Physiol &

Cell Biol Chuo Ku Div Comparat Pathophysiol Kusunoki Cho;

Tokushima Bunri Univ Fac Pharmaceut Sci Med Chem Yamashiro Tokushima 7708514 Japan;

Tokushima Bunri Univ Fac Pharmaceut Sci Med Chem Yamashiro Tokushima 7708514 Japan;

Tokushima Bunri Univ Fac Pharmaceut Sci Med Chem Yamashiro Tokushima 7708514 Japan;

Kyushu Univ Med Inst Bioregulat Div Metabol Higashi Ku 3-1-1 Maidashi Fukuoka 8128582 Japan;

Kobe Univ Grad Sch Med Dept Physiol &

Cell Biol Chuo Ku Div Comparat Pathophysiol Kusunoki Cho;

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正文语种 eng
中图分类药理学;
关键词
Adipose tissue accumulation; Gene expression; D-47; Lipid-lowering effects; Lipidome analyses; Liver lipid contents;

机译：脂肪组织积累;基因表达;D-47;脂质降低效果;脂质体分析;肝脂肪含量;

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专利

1. Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits) [J] . Tamura Shohei, Koike Yui, Takeda Hiroaki, European Journal of Pharmacology: An International Journal . 2018,第期

机译：D-47，一种新开发的化合物，在家庭高胆固醇血症动物模型中对新开发的化合物（Whhlmi兔）的脂质代谢的改善效果
2. Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia [J] . Shiomi Masashi, Takeda Hiroaki, Irino Yasuhiro, Atherosclerosis . 2019,第期

机译：鉴定新型血清标志物，用于冠状动脉粥样硬化的进展，家族性高胆固醇血症的动物模型
3. Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia [J] . Satoshi YAMADA, Tomonari KOIKE, Takayuki NAKAGAWA, Experimental Animals . 2017,第2期

机译：家族性高胆固醇血症动物模型WHHLMI兔（穴兔）冠状动脉斑块的形态学特征
4. An Experiment Research on the Effect of Zhi Gan Qing on Lipid Metabolism in the Hyperc-holesterolaemia Model of Rabbit [C] . The Third international congress on TCM : Collection of papers . 2001

机译：治肝清对家兔高胆固醇血症模型脂质代谢影响的实验研究
5. Familial combined hyperlipidemia: Genetic, biochemical, and animal model approaches [D] . Mar, Rebecca Ann 2006

机译：家族性合并高脂血症：遗传，生物化学和动物模型方法
6. Electrocardiograms Corresponding to the Development of Myocardial Infarction in Anesthetized WHHLMI Rabbits (Oryctolagus cuniculus) an Animal Model for Familial Hypercholesterolemia [O] . Tsutomu Kobayashi, Takashi Ito, Satoshi Yamada, 2012

机译：心电图与麻醉的WHHLMI兔（穴兔（Oryctolagus cuniculus）一种家族性高胆固醇血症的动物模型）的心肌梗死的发展相对应
7. Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits) [O] . Shohei Tamura, Yui Koike, Hiroaki Takeda, 2018

机译：D-47，一种新开发的化合物，在家庭高胆固醇血症动物模型中对新开发的化合物（Whhlmi兔）的脂质代谢的改善效果

Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

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