A Systematic Synthetic Study of the Aqueous Chemistry of Binary Boron–Hydroxycarboxylic Acid Systems: Boron Structural Speciation Correlation to the Biotoxicity Profile

摘要

> In an attempt to delve into the chemistry of boron, whose role in biology still remains unclear, yet its presence and influence is undisputed, research was launched into the structural speciation of B III with physiological binders. The latter molecules involve hydroxycarboxylic glycolic, 2‐hydroxy‐isobutyric, and citric acids. Their pH‐specific reactivity is systematically investigated synthetically in binary and ternary systems of B III , leading to well‐defined crystalline materials, [B(OCH ₂ COO) ₂ ](CH ₆ N ₃ ) ( 1 ), Na[B{OC(CH ₃ ) ₂ COO} ₂ ] ( 2 ), [B(C ₆ H ₆ O ₇ ) ₂ ](CH ₆ N ₃ ) ( 3 ), [B(C ₆ H ₆ O ₇ ) ₂ ](C ₃ H ₅ N ₂ ) ( 4 ), {Na ₄ [B(C ₆ H ₅ O ₇ )(C ₆ H ₄ O ₇ )]} _n · 2 n H ₂ O ( 5 ), and K[B(C ₆ H ₆ O ₇ ) ₂ ] ?