Fluorine-18: A radionuclide with diverse range of radiochemistry and synthesis strategies for target based PET diagnosis

摘要

Fluorine-18 is one of the most widely used radionuclides for the production of radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods like nucleophilic, electrophilic, Cu mediated mechanisms or prosthetic groups are widely using to achieve high regioselective radio-chemical yields. It acts as a powerful tool to identify new drug targets through cellular uptake, pharmacokinetic (ADME) and pharmacodynamic parameters of the F-18 labeled tracer or drug. These PET tracers have been developed based on the receptors expressed in a disease condition. A number of F-18 radiotracers have been developed against the Tropomyosin Receptor Kinases (Trks), Carbonic anhydrases (CAs), Epidermal Growth Factor Receptors (EGFR), Poly ADP ribose polymerase (PARP) etc. for the diagnosis in cancer therapy. The current research also focused on the development of novel F-18 radiotracers for neurological conditions for deciphering underlying physiology in diseases like Alzheimer, and Parkinson. Therefore, in this review we have focused on F-18 labeling methods, and radiotracers developed against common cancers and neurological conditions. (C) 2019 Elsevier Masson SAS. All rights reserved.