Critical attributes of formulation and of elaboration process of PLGA-protein microparticles

摘要

Low drug loading, burst effect during release and drug inactivation account for the main drawbacks of protein microencapsulation in poly(D, L-lactic-co-glycolic) acid (PLGA) matrix by the water-in oil-in water (W/O/W) solvent evaporation method. Thus, the current study was set to invest the critical attributes of formulation and of elaboration process which determine protein loading into microparticles as well as its further release, using albumin as protein model.