Response: Arrhythmias 72 hour post strenuous exercise at a time when cardiac troponin was not elevated

摘要

Thank you for your comment on our paper [1 ] regarding the significance of measuring cardiac troponin (cTn) 72-hour after strenuous exercise.We agree that cTn was likely to have been elevated during this multi-day ride (e.g., [2]), indicating disruption to the microscopic structure of cardiac muscle [3] and/or leakage of troponin through other mechanisms [4,5]. Cardio-healthy people display this response without irreversible myocardial impairment [5]. However, high sensitivity cTn concentrations were <4 ng/L at 72-hour post-exercise, demonstrating that post-exercise measures were taken when no evidence existed of very recent cardiac disturbance. We never suggested that cardiac damage had, or had not, occurred during the ride.